More Science, Less Fat®
Whether your practice already enjoys the benefits of offering the CoolSculpting® Procedure to your patients, or you simply want to learn more about this exciting new technology, we strive to keep you informed with our comprehensive clinical education programs.
SCIENTIFIC STUDIES AND PUBLICATIONS
Based on early experiments conducted by scientists Dieter Manstein, MD, PhD and R. Rox Anderson, MD, of the Wellman Center of Photomedicine at Massachusetts General Hospital in Boston, a teaching affiliate of Harvard Medical School, Cryolipolysis, the concept behind CoolSculpting was invented.
Read about Cryolipolysis and the CoolSculpting Procedure in the following peer-reviewed articles and clinical studies:
“Cryolipolysis for Reduction of Excess Adipose Tissue”
A comprehensive review of the literature associated with Cryolipolysis was performed by a team of researchers at the University of California, Los Angeles and Massachusetts General Hospital and found:
- Subcutaneous fat layer reduction of up to 50% can occur following a single cryolipolysis treatment.
- Cold exposure results in apoptosis of the adipocytes, followed by an inflammatory infiltrate. Ultimately, the inflammatory infiltrate results in phagocytosis and mobilization of the treated adipocytes.
- The decrease in fat thickness occurs gradually over the first 3 months following treatment, and is most pronounced in patients with limited, discrete fat bulges.
- Erythema of the skin, bruising, and temporary numbness at the treatment site are commonly observed following treatment with the device, though these effects largely resolve in approximately 1 week.
- There have been no reports of scarring, ulceration, or alterations in blood lipid or liver function profiles.
Learn more on PubMed.gov »
“Cryolipolysis for Subcutaneous Fat Layer Reduction”
A literature review by Matthew Avram, MD, of the Dermatology Laser & Cosmetic Center at Massachusetts General Hospital, detailed the concept of Cryolipolysis as well as the animal and human clinical study results which showed that:
- Cryolipolysis has demonstrated efficacy in both human and animal studies.
- Histology findings confirmed the selective reduction of fat in both humans and animals, with evidence of a gradual thinning of the fat layer over a period of two to four months.
- Cryolipolysis has not produced any significant adverse side effects in studies to date and any noted effects have been minor and temporary.
Learn more on PubMed.gov »
"A Prospective Clinical Study of Noninvasive Cryolipolysis for Subcutaneous Fat Layer Reduction"
The multi-center, prospective, non-randomized, IRB-approved study was led by distinguished experts Jeffrey Dover, MD, director of SkinCare Physicians in Chestnut Hill, MA, and Elizabeth Tanzi, MD, co-director of the Washington Institute of Dermatologic Laser Surgery in Washington, DC.
Study results corroborated earlier research showing that precisely controlled cooling with the CoolSculpting device causes a gradual reduction of targeted fat cells through induced apoptosis without harming surrounding tissues.
In this interim report of the initial group of treated subjects, clinical results, photographic evaluation and physician assessment demonstrated that:
- 100% of a subset of ultrasound-evaluated subjects demonstrated a measurable reduction; the average for the group was 22.4% fat layer reduction 4 months post-procedure.
- 27 of 28 (96%) properly selected subjects (discrete fat bulges) had discernable efficacy.
View the poster »
"Selective Cryolysis: A Novel Method of Non-Invasive Fat Removal"
This initial work by Drs. Manstein and Anderson and their team focused on the effect of controlled cooling on subcutaneous fat in an experimental animal model. They demonstrated that:
- At 3.5 months... approximately 80% of the upper fat layer thickness, or 40% of the total fat layer thickness, was removed in the cold exposure site.
- Prolonged, controlled local skin cooling can induce selective damage and subsequent loss of subcutaneous fat, without damaging the overlying skin.
- No evidence of increased blood lipid levels at multiple intervals up to 90 days post-procedure.
- Lipid-laden mononuclear cells at 2 weeks and beyond strongly suggest that the adipocytes are undergoing apoptosis and being removed by phagocytosis.
Learn more on PubMed.gov »
"Cryolipolysis for Noninvasive Fat Cell Destruction: Initial Results from a Pig Model"
Early research led by Brian Zelickson, MD, of the University of Minnesota Medical School, examined whether Cryolipolysis can selectively damage subcutaneous fat without damaging the overlying skin or causing an increase in lipid levels. Dr. Zelickson and his study team validated the following results:
- Fat layer reduction of up to 1 cm after a single exposure.
- Confirmed by both gross pathology and ultrasound imaging measurements.
- Cholesterol and triglyceride levels did not exceed normal bounds.
- No damage to overlying skin or surrounding structures confirmed by both clinical observation and histology.
Learn more on PubMed.gov »
“Non-Invasive Cryolipolysis for Subcutaneous Fat reduction Does Not Affect Serum Lipid Levels or Liver Function Tests”
A multi-site study examined the effect of Cryolipolysis on serum lipids (cholesterol, triglycerides, etc.) and liver function test results and showed:
- No damage to overlying skin or surrounding structures confirmed by clinical observation.
- No meaningful changes in mean values were observed for any blood lipid level or liver test at any point over the 12-week follow-up period.
Learn more on PubMed.gov »
"Efficacy and Neurological Effects of Noninvasive Cryolipolysis in Humans"
Designed to determine if fat reduction in humans caused by cold exposure is associated with local sensory function or nerve fiber changes. Conducted by leading plastic surgeon Sydney R. Coleman, MD, New York University School of Medicine; Kulveen Sachdeva, MD, San Ramon Regional Medical Center, California; and Barbara M. Egbert, MD, Stanford University Medical Center; et al.
- Ultrasound measurements confirmed non-invasive Cryolipolysis resulted in substantial fat reductions within 2 months of treatment without damage to the skin.
- Transient reduction in sensation occurred in 6 of 9 subjects assessed by neurologic evaluation. All sensation returned by a mean of 3.6 weeks post-treatment. No lasting sensory alterations or observations of skin damage in any subjects evaluated.
- Special staining techniques to highlight epidermal nerve fibers demonstrated no significant long-term change in nerve fiber structure.
Learn more on PubMed.gov »
